Current understanding of ovarian aging
نویسندگان
چکیده
منابع مشابه
Mitochondria in oocyte aging: current understanding
The oocyte is the largest cell found in multicellular organisms. Mitochondria, as the energy factories for cells, are found in high numbers in oocytes, as they provide the energy for oocyte maturation, fertilization, and embryo formation via oxidative phosphorylation. Failure of assisted reproduction is mainly attributed to oocyte aging and increased aneuploidy. As the most numerous organelle i...
متن کاملAn Update on Ovarian Aging and Ovarian Reserve Tests
Ovaries are the female organs that age more quickly than other tissues such as the uterus, the pituitary gland or pancreas. Different from males, an interesting question is why and how the females lose fertility so rapidly. During the aging process, both the number and quality of the oocytes in the ovaries decrease and reach to a point beyond that no more viable offspring may be produced and th...
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Factor XIII or "fibrin-stabilizing factor," is a transglutaminase circulates in the blood circulation as a hetero tetramer with two catalytic A subunits and two carrier B subunits. This important coagulation factor has a crucial role in clotting cascade and produces strong covalent bonds between soluble formed fibrin monomers during coagulation. This stable cross linked fibrin strands are resis...
متن کامل//Ovarian Aging
With age, there is a decline in both the quantity and quality of the pool of follicles and oocytes. Linear extrapolation of follicular depletion in women with regular menses predicts that, by 50 years of age, each ovary would contain 2500 to 4000 primordial follicles. Because the menopausal ovary is largely devoid of follicles, follicular depletion apparently accelerates in the last decade of r...
متن کاملOvarian aging and premature ovarian failure.
Physiological reproductive aging occurs as a result of a decrease in the number and quality of oocytes in ovarian cortex follicles. Although the reason for the decrease in the quality of the pool and follicular oocytes is not fully understood, endocrine, paracrine, genetic, and metabolic factors are thought to be effective. Nowadays, in order to understand the mechanisms of ovarian aging, genom...
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ژورنال
عنوان ژورنال: Science China Life Sciences
سال: 2012
ISSN: 1674-7305,1869-1889
DOI: 10.1007/s11427-012-4352-5